New Step by Step Map For ceesdekker
New Step by Step Map For ceesdekker
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Rotary movement of DNA rotors on nanopores. Prime row: raw movie in the Cy5 channel of each and every rotor. Center row: corresponding single-particle localization effects of both of those ends of the DNA rotors. The situation of the current body is marked as orange and blue dots, and the trajectory of The ten frames prior to The existing frame is demonstrated as strong traces.
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Dynamics of initiation, termination and reinitiation of DNA translocation via the motor protein EcoR124I
2007, very first serious-time detection of strand exchange in homologous recombination by RecA; discovery of a very low persistence length of ends of microtubules; and fixed the mechanism of biosensing with carbon nanotubes
Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond smart design and style in 2005. (nl)
Cornelis (Cees) Dekker (Haren, seven april 1959) is een Nederlandse natuurkundige en universiteitshoogleraar verbonden aan de Technische Universiteit Delft. Van 2010 tot en fulfilled 2018 was hij tevens directeur van het Kavli Institute of Nanoscience in Delft. Zijn vakgebied is de moleculaire biofysica; hierbij beweegt hij zich op het grensvlak van de natuurkunde en de biologie waarbij hij gebruikmaakt van de zogeheten nanotechnologie, de technieken om aan enkele atomen en moleculen te kunnen meten.
What distinguishes biology from chemistry is these factors collectively make up a dwelling technique. The trick of explained life, I feel, lies within the interactions, the interplay of those molecules. The large dilemma with regards to the origin of daily life remains unanswered. How did we ever evolve from uncomplicated molecules into the really complex techniques we see now? We have no idea. I would like to operate on these kinds of huge, open up questions.’
Move-pushed rotary motors such as windmills and water wheels push useful procedures in human Modern society. Even though examples of these kinds of rotary motors also element prominently in mobile biology, their artificial design at the nanoscale has remained difficult. Listed here we reveal move-driven rotary movement of the self-structured DNA nanostructure that is docked onto a nanopore in a thin strong-state membrane. An elastic DNA bundle self-assembles into a chiral conformation upon phoretic docking onto the solid-state nanopore, and subsequently displays a sustained unidirectional rotary movement of up to twenty rev s−one.
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At the moment, we also understood that it should be feasible to use one semiconducting carbon nanotube to produce a transistor — and we set out to make it. We stretched unique semiconducting nanotubes throughout metallic electrodes and applied the underlying silicon substrate as being a gate electrode, setting up the basic 3-terminal ceesdekker structure of a area-effect transistor (Fig.
[14] In 2005 Dekker grew to become involved with Netherlands-wide discussions about Smart Design, a motion that he has given that Evidently distanced himself from. Dekker advocates that science and faith are usually not in opposition but could be harmonized.
1999, initially measurement from the wavefunction of solitary molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive proof for any new Luttinger description of interacting electrons in nanotubes
2005, discovery of the mechanism of DNA uncoiling by topoisomerase enzymes; discovery of extensive-assortment conformational changes in Mre11/DNA repair service complexes; and very first force measurements on the DNA molecule in the nanopore
Case in point (2) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is demonstrated in grey, the rim of your pore is highlighted in crimson, in addition to a 3D rendering on the movement in the DNA rod is displayed.